Risk Prediction Models of Cardiotoxicity in Patients With Breast Cancer
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Early detection and treatment of cardiotoxicity are essential for reducing cardiac events. However, a reliable predictive model for cardiotoxicity in patients with breast cancer receiving chemotherapy is lacking. OBJECTIVES: In this study, we aimed to develop a risk prediction model and establish effective surveillance for cardiotoxicity in patients with breast cancer undergoing chemotherapy. METHODS: Patients with breast cancer scheduled for neoadjuvant and/or adjuvant chemotherapy were prospectively screened at 25 participating institutions between August 2017 and March 2020. Cardiotoxicity was defined as a reduction in left ventricular ejection fraction of >10% from baseline to a value <53%. RESULTS: The study included 559 chemotherapy-naïve female patients. Cardiotoxicity was observed in 46 of 559 patients (8.2%) during a median follow-up period of 366 days (Q1-Q3: 365-367 days). The CHECK HEART (Comprehensive Heart Imaging to Evaluate Cardiac Damage Linked With Chemotherapy in Breast Cancer Patients) score consisted of 6 variables: heart rate, left ventricular global longitudinal strain, left ventricular end-systolic and end-diastolic diameters, right ventricular fractional area change, and treatment with anthracycline and trastuzumab. The time-dependent area under the receiver operating characteristic curve (AUC) at 12 months based on pretreatment data showed acceptable accuracy (AUC: 0.82; 95% CI: 0.76-0.89). CONCLUSIONS: The developed multivariable risk prediction models can accurately predict cardiotoxicity and support effective surveillance in patients with breast cancer receiving chemotherapy.
Source: JACC Asia
Authors: Yosuke Terui, Kotaro Nochioka, Hideki Ota, Hiroshi Tada, Haruka Sato, Satoshi Miyata, Shigeru Toyoda, Shu Inami, Akihiro Nomura, Masaya Shimojima, Yasuhiro Izumiya, Yusuke Kodama, Takeshi Kitai, Kaoru Iwabuchi, Shu Suzuki, Daisuke Kitano, Keisuke Kida, Kiyotaka Shibuya, Takuya Oikawa, Takeru Nabeta, Toshiyuki Yano, Hiroyuki Iwano, Masayoshi Oikawa, Tatsuhiro Shibata, Yutaka Miura, Yoshito Ogihara, Nobuyuki Komiyama, Hiroshi Kato, Koji Higuchi, Sakiko Miyazaki, Yugo Yamashita, Satoshi Yasuda, Koichiro Sugimura
Institutions: Tohoku University, Teikyo University, Dokkyo Medical University, Kanazawa University, Osaka Metropolitan University, SHOWA Medical University, National Cerebral and Cardiovascular Center, Kobe City Medical Center General Hospital, Osaki Citizen Hospital, KKR Tohoku Kosai Hospital, Nihon University, St. Marianna University School of Medicine, Saka General Hospital, Kitasato University Hospital, Kitasato University, Sapporo Medical University, Hokkaido University, Fukushima Medical University, Kurume University, Tohoku Medical and Pharmaceutical University, Mie University, Mie University Hospital, St. Luke's International Hospital, Miyagi Prefectural Hospital Organization, Kagoshima University, Juntendo University, Kyoto University, International University of Health and Welfare Narita Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,084
OpenAlex ID: W4414715411