Work

Pioneering Cu(II)-flavonoid coordination polymers with anticancer activity

Year: 2025

Type: article

Abstract: Herein, we report the synthesis and structural characterization of the first Cu(II)–flavonoid two-dimensional coordination polymer, [Cu(chry)(phen)]⋅H₂chry⋅0.75H₂O. Among three synthetic approaches – microwave-assisted, solvothermal, and conventional reflux – the microwave method proved most efficient, yielding the compound in 5 min at 100 °C with 82 % yield. In vitro studies demonstrated strong anticancer activity against Caco-2 cells, with ∼98 % and ∼71 % reductions in cell viability at 10 μM, as determined by SRB and MTT assays, respectively, significantly surpassing the activity of the free ligands. The compound also caused substantial membrane damage (LDH release) and fully inhibited cell proliferation (IC₅₀ = 1.83 μM, [ 3 H]-thymidine assay), confirming its high anticancer potential. The first flavonoid-based two-dimensional coordination polymer, {[Cu(chry)(phen)]·(H₂chry)}ₙ, was synthesized using three approaches—microwave, solvothermal, and reflux—with the microwave method proving the most efficient (5 min, 82 % yield). In vitro assays against Caco-2 cells revealed pronounced cytotoxicity (∼98% and ∼71 % reduction in viability at 10 μM, as determined by SRB and MTT assays, respectively), significant membrane damage (LDH release), and complete inhibition of proliferation (IC₅₀ = 1.83 μM), highlighting its strong anticancer potential. • First 2D Cu(II)–flavonoid coordination polymer was synthesized and characterized. • Microwave-assisted synthesis afforded 82 % yield in 5 min at 100 °C. • The compound reduced Caco-2 cell viability by up to 98 % at 10 μM. • It inhibited cell proliferation and disrupted membrane integrity in vitro .

Source: Inorganic Chemistry Communications

DOI: 10.1016/j.inoche.2025.115628