Intensive care unit outcomes and prognostic factors of colorectal cancer
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers and CRC patients are among the most common intensive care unit (ICU) admitted cancer patients. However, their prognosis and evaluation methods are rarely studied. AIM: To determine the short-term mortality outcome and identify the potential prognostic factors of CRC cancer patients admitted to the ICU. METHODS: A multicenter cross-sectional study was performed from May 10, 2021 to July 10, 2021 at the ICU departments of 37 cancer specialized hospitals in China, and included patients aged ≥ 14 years with ICU duration ≥ 24 hours. Clinical records of patients with a primary CRC diagnosis were reviewed. Patients were separated into groups according to 90-day survival. Characteristics between groups were compared. Univariate and multivariate regression tests were used to analyze the correlated factors of ICU outcomes. Predictive values of disease severity scores were assessed using receiver operating characteristic curve analysis. RESULTS: In total, 189 CRC patients were included in the study. The 90-day mortality was 12.2%. Patients who died showed differences compared to patients who survived mostly in terms of disease severity and ICU complications. It appears that patients admitted to the ICU from a clinical ward due to emergencies may have a higher risk of mortality while surgical management was associated with better survival. In multivariate analysis, only chemotherapy, elective surgery and conventional oxygen therapy were identified as independently correlated with 90-day mortality. Sequential organ failure assessment and acute physiology and chronic health evaluation II scores had moderate accuracy in predicting short-term mortality. CONCLUSION: ICU admitted CRC patients appear to have low short-term mortality which requires further confirmation in prospective studies. The prognostic tools for these patients need further optimization.
Authors: Qian Dong, Rui Xia, Xue-Zhong Xing, Chang-Song Wang, Gang Ma, Hong-Zhi Wang, Biao Zhu, Jiang-Hong Zhao, Dong-Min Zhou, Li Zhang, Ming-Guang Huang, Rong-Xi Quan, Yong Ye, Guo-Xing Zhang, Zheng-Ying Jiang, Bing Huang, Shan-Ling Xu, Yun Xiao, Lin-Lin Zhang, Rui-Yun Lin, Shu-Liang Ma, Yu-An Qiu, Zhen Zheng, Ni Sun, Le-Wu Xian, Ji Li, Ming Zhang, Zhi-Jun Guo, Yong Tao, Xiang-Zhe Zhou, Wei Chen, Dao-Xie Wang, Ji-Yan Chi, Dong-Hao Wang, Kai-Zhong Liu
Institutions: Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Tianjin Medical University Cancer Institute and Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Cancer Hospital of Chinese Academy of Medical Sciences, Harbin Medical University, Third Affiliated Hospital of Harbin Medical University, Sun Yat-sen University Cancer Center, Peking University Cancer Hospital, Fudan University, Fudan University Shanghai Cancer Center, Hunan Cancer Hospital, Henan Cancer Hospital, Hubei Cancer Hospital, Shanxi Provincial Cancer Hospital, Tumor Hospital of Xinjiang Medical University, Fujian Medical University, Fujian Provincial Cancer Hospital, Jilin Province Tumor Hospital, Chongqing University, Chongqing Cancer Hospital, Guangxi Medical University, Tumor Hospital of Guangxi Medical University, Sichuan Cancer Hospital, Cancer Hospital of Shantou University Medical College, Jiangsu Cancer Hospital, Jiangxi Provincial Cancer Hospital, Liaoning Cancer Hospital & Institute, Guangzhou Medical University Cancer Hospital, Hangzhou Cancer Hospital, Shandong Tumor Hospital, Shandong First Medical University, Nantong University, Nantong Tumor Hospital, Gansu Provincial Cancer Hospital Gansu Provincial Academic Instiute for Medical Research, Capital Medical University, Beijing Shijitan Hospital
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415062066