Year: 2025
Type: article
Study design: Observational Study
Abstract: Background . Women of reproductive age account for 40% of all patients suffering from epilepsy in Russia. Epilepsy course varies during pregnancy as follows: full control (up to 66%) is achieved in most cases; alternatively, incidence of epileptic episodes remains unaltered, but disease course may deteriorate in as high as 15.8% cases. The current study was conducted within the framework of creating the Russian Register of Pregnancy and Epilepsy. Objective : Analysis of epidemiological indicators of epilepsy and epileptic syndromes among pregnant women in the Smolensk Region. Material and methods. Medical documentations of pregnant, parturient and puerperant women examined by a neurologist due to generalized and partial seizures in the anamnesis or occurring in ongoing pregnancy in the years 2019 and 2024 were retrospectively analyzed at the Perinatal Center of the Multidisciplinary Hospital of the Clinical Hospital No. 1 (Smolensk). Epilepsy epidemiology and pattern in pregnant women in the Smolensk Region were studied by assessing and discussing received medications, delivered obstetric care, as well as fetal congenital malformations. Results . The total number of pregnant patients with a history of epilepsy and epilepsy syndrome comprised 28 in 2019 (7.35% of all neurological pathology cases), and 28 in 2024 (6.41%). The study demonstrated type-specific epilepsy pattern including generalized epilepsy (71.4% in 2019, 68.2% in 2024), partial epilepsy (28.6% in 2019, 31.8% in 2024). In addition, anti-epileptic therapy was assessed showing significantly increased percentage of lamotrigine use in 2024 compared to 2019 (р=0,0086). The decline in prevalence of valproic acid use in 2024 vs 2019 was insignificant (р=0,26), with the existing experience of congenital fetal malformations. The choice of delivery tactics in patients with epilepsy was in favor of Caesarean section. Conclusion. The results suggest a need for further retro- and prospective analysis to improve managing pregnant and parturient women with epilepsy.
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $142
OpenAlex ID: W4415282973