Work

Association Between Serum Interleukin-41 Levels and Breast Cancer Status: A Case–Control Study in Iraqi Women

Year: 2025

Type: article

Abstract: Introduction: Breast cancer is the most common malignancy among women worldwide.Interleukin-41 (IL-41) is a novel cytokine with immunomodulatory functions.This study aimed to evaluate serum IL-41 levels in breast cancer patients compared with healthy women.Methods: A case-control study was conducted on 60 breast cancer patients (20-41 y) and 30 healthy age-matched women (20-40 y) recruited from the Teaching Oncology Hospital, Baghdad (Dec 2023-Mar 2024).Demographic data were recorded.Serum IL-41 was measured using ELISA; liver enzymes GOT and GPT were assessed by spectrophotometry.Mann-Whitney U test and Cliff's delta were used for analysis.Results: Median IL-41 levels were significantly higher in patients compared to controls (p<0.001,Δ=0.75; p=0.002,Δ=0.80).GPT was also elevated in patients (p=0.004,Δ=0.45; p=0.01,Δ=0.60), while GOT showed no significant difference (p>0.05).Conclusion: IL-41 may serve as a promising biomarker for breast cancer independent of age.Elevated GPT may indicate hepatic involvement.Further studies are required to validate these findings.

Source: Journal of Breast Diseases

DOI: 10.61882/ijbd.18.3.5

Authors: Zahraa A.G. AL Ghuraibawi, istikrar Muslem Hade, Ali Abd AL-Hussain Mahdi, Mareym Majid Alkhaiat, Zainab Ghazi Sadeq

Institution: Middle Technical University

Language: Persian

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4415322005