Work

Sjögren’s Syndrome is Rare in Psoriasis, but Common in Psoriatic Arthritis: Two Sides of a Coin – A Single Centre Retrospective Study

Year: 2025

Type: article

Abstract: KEY MESSAGES What is already known about this subject? Secondary Sjögren's syndrome (sSS) may accompany autoantibody-driven diseases such as rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis. What does this study add? The higher frequency of Anti-Nuclear Antibody (ANA) positivity and sSS in psoriatic arthritis (PsA) compared to psoriasis (PsO) suggest that B lymphocyte-driven immunopathogenic pathways may contribute to the emergence of PsA. How might this impact clinical practice? Sjögren's syndrome (SS) seems to be part of the clinical picture in a substantial proportion of PsA patients, and its absence in PsO implies that SS may be arthritis-associated. ABSTRACT Background: Sjögren's syndrome (SS) may accompany psoriatic arthritis (PsA), if ever, and its presence during psoriasis (PsO) is rare. Recent observations of an association with predominantly axial forms of PsA are intriguing. Whether SS complicates PsO and PsA to the same extent is not known. Objectives: To investigate the frequency of SS in patients with PsO and PsA, and elucidate disease features associated with SS. Methods: In this retrospective analysis, we collected the data about previously recorded in the follow-up files of PsO and PsA patients. We classified patients who met the 2002 American-European Sjögren's syndrome Consensus Group Criteria (AECG) or the 2016 ACR-EULAR Classification Criteria for primary Sjögren's Syndrome as SS. Frequency rates of SS in PsA patients and in PsO patients without arthritis were compared and SS characteristics were described. Results: Of the 184 PsO patients, 112 had PsA and 72 PsO alone. A substantial proportion of PsA patients had SS. This association was not present in the PsO group (PsA: 20(%17.9), PsO: 0(%0), p<0.001). Gender distribution, mean age, and PsO onset age were similar in both. Symmetric polyarticular involvement was rare, and most PsO patients with arthritis were ANA positive at a serum dilution level of 1:320 and beyond. Conclusions: SS seems to be part of the clinical picture in a substantial proportion of PsA patients, and its absence in PsO implies that SS may be arthritis associated. Whether the type of arthritis is critical in developing SS in PsA deserves further studies with large populations. Cite this article as: Abacar K, Çolakoğlu-Özkaya Ş, Ergun T, Aliyeva A, Kutluğ-Ağaçkiran S, Sevik G, Küçükoğlu-Cesur S, Soy M, Atagündüz P. Sjögren’s Syndrome is Rare in Psoriasis, but Common in Psoriatic Arthritis: Two Sides of a Coin – A Single Centre Retrospective Study. Mediterr J Rheumatol 2025;36(3):403-409. Article Submitted: 27 Feb 2024; Revised Form: 26 Apr 2024; Article Accepted: 29 May 2024; Available Online: 28 May 2025 This work is licensed under a Creative Commons Attribution 4.0 International License. ©2025 The Author(s). https://doi.org/10.31138/mjr.270224.tcs

Source: Mediterranean Journal of Rheumatology

DOI: 10.31138/mjr.270224.tcs