The Effects of Core Stabilization Exercise and Vitamin D intake on the Levels of Tumor Necrosis Factor-α and Interleukin-10 in Women with Chronic Low Back Pain
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: Background and Objectives: Chronic back pain is a multifactorial disease that can be affected by vitamin D deficiency, inflammatory conditions, and sedentary lifestyle.The aim of this study is to compare the effect of core stabilization exercises with vitamin D supplementation on the levels of tumor necrosis factor-alpha (TNF-α) and interleukin 10 (IL-10) in women with low back pain. Materials & Methods:This semi-experimental study was conducted on 48 women suffering from chronic back pain, who were placed in 4 groups: control, exercise, vitamin D, and exercise + vitamin D. The exercise program included 6 core stabilization exercises performed in 3 sets with 8-10 repetitions and 1 minute rest between movements.Vitamin D was taken weekly with a dose of 50,000 international units.TNF-α and IL-10 levels were measured before and after 8 weeks by ELISA method.Results: Vitamin D levels in all subjects were lower than normal levels.8 weeks of central stabilizing exercises, vitamin D and combined intervention led to a decrease in TNF-α serum levels and an increase in IL-10 (P<0.001).In addition, the effect of the combined intervention in increasing IL-10 was greater compared to the other two therapeutic interventions (P<0.001)Conclusion: It seems that low levels of vitamin D are commen in patients with chronic back pain and performing central stabilization exercises, vitamin D consumption and a combination of these two interventions can lead to improvement of inflammation in people with back pain with low levels of vitamin D due to decrease TNF-α and positive regulation of IL-10.
Authors: M Biyabani, F Ghafari, S Aaali, M Habibian
Institution: Qaemshahr Islamic Azad University
Language: Persian
Field: Health Professions
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4415340883