Work

[Construction and application of oral squamous cell carcinoma organoid bank].

Year: 2025

Type: article

Abstract: H3K4me3/H4K16ac epigenetic reprogramming, activating epithelial-mesenchymal plasticity (EMP) and inducing partial epithelial-mesenchymal transition (pEMT). This "holographic patient-mirroring" platform provided unprecedented resolution for OSCC precision therapy and had been formally incorporated into the Chinese Stomatological Association Technical Guidelines (Technical guideline for establishing patient-derived oral squamous cell carcinoma organoid banks, CHSA 2024-08). Future integration of immune-competent organoids, 3D-bioprinted vasculature, and multi-omics-AI systems will accelerate personalized oncology. These innovations will accelerate clinical translation of personalized therapeutic regimens, ultimately bridging the gap between bench research and bedside application.

Source: Europe PMC (PubMed Central)

DOI: 10.19723/j.issn.1671-167x.2025.05.006

Authors: Shang Xie, Luming Wang, Xinyuan Zhang, Qiushi Feng, Yangyang Xia, Ziwei Dai, Xiaofeng Shan, Zhigang Cai

Institutions: Peking University, Peking University School and Hospital of Stomatology

Language: Chinese

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4415544488

FWCI:

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