Year: 2025
Type: preprint
Study design: Observational Study
Abstract: We previously identified and confirmed a positive association between plasma protein LEG1 homolog and incident post-menopausal breast cancer risk in two prospective cohort studies that measured the protein using the SomaScan platform. To further confirm this finding in a cohort that used a different proteomics platform, Olink, we investigated this association in the UK Biobank. Among 9,537 post-menopausal, White women followed for a median of 11 years and with protein data, 295 breast cancer cases were identified. Adjusting for breast cancer risk factors, per doubling, the hazard ratio was 1.14 (95% confidence interval CI 0.96-1.35). While the direction of association was consistent, the magnitude was not as strong as in our prior two cohorts (HR per doubling: 1.45, 1.24) and not statistically significant. Data from the UK Biobank provide modest support for plasma protein LEG1 homolog as a risk factor for post-menopausal breast cancer. A quantitative targeted assay is needed.
Source: medRxiv
Institutions: Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, University of Zurich, University Hospital Zurich, Centre international de recherche sur le cancer, Imperial College London, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, University of Oxford
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4415701616