Work

Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorder

Year: 2025

Type: article

Study design: Observational Study

Source: Brain Behavior and Immunity

DOI: 10.1016/j.bbi.2025.106156

Authors: Fulton T. Crews, Liya Qin, Leon Coleman, Elena Vidrascu, Ryan Vetreno

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Center for Alcohol Studies, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill

Awards: UNC-CH NADIA Scientific Core, 5/8 NADIA U01 Effects of Adolescent Alcohol on adult brain Neurocircuitry, G3112896361, G3143527604, G399746468, G5153429243, G6982471701, 1/1 NADIA U24 Administrative Core, 2/2 Mechanisms of alcohol pathology: A collaborative partnership between NCCU & UNC, Microglia Activation and TLR-induced Neurodegeneration by Alcohol Promotes Progression of Alzheimer Pathology, ETHANOL EFFECTS ON NEUROTRANSMISSION, Ethanol modulate central and peripheral immune responses via HMGB1, IL-1Beta, and other Immune Signaling Molecules, G8439781573, G9000278734, 2/2 Partnerships to Enhance Alcohol Research Across NCCU and UNC (PEAR-NC), Molecular and Cellular Alcohol Research Training, 3D Human neurocircuits to determine the role of microglia in AUD and Alzheimer's neuronal pathology

OpenAlex ID: W4415717153

FWCI: 1.767

Cites: 82

Cited by: 6

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