Clinical Impact of Systemic Treatment Choices Made in Current Practice in Elderly Patients with Atopic Dermatitis
Year: 2025
Type: article
Study design: Observational Study
Abstract: Increasing life expectancy will lead to more elderly people with atopic dermatitis; however, analyses of the impact of atopic dermatitis therapy on the elderly are lacking. This prospective, multicentre observational study assessed the effect of treatment choice on the efficacy of atopic dermatitis therapies in patients with atopic dermatitis aged ≥ 65 years vs < 65 years in France. Clinical endpoints assessed included changes in Eczema Area and Severity Index scores, atopic dermatitis-related hospitalizations, and quality of life. Between December 2020 and October 2024, 679 patients were included in the study (≥65 years: n = 83; < 65 years: n = 596). At baseline, most patients had moderate/severe atopic dermatitis. Biological therapy was the most common treatment initiated at the enrollment visit (≥ 65 years: 72.3%; < 65 years: 54.0%). At 12 months, the mean Eczema Area and Severity Index score decreased similarly in both groups (p = 0.845), from 17.6 ±9.6 to 3.7 ± 5.2 for patients aged ≥ 65 years and from 18.4 ±12.3 to 4.3 ± 5.5 for those aged < 65 years. The reduction in number of atopic dermatitis-related hospitalizations was significant and similar in both groups, and quality of life improved across all areas. Overall, results suggest that therapeutic choices made by dermatologists have a positive impact on elderly patients with atopic dermatitis.
Source: Acta Dermato Venereologica
Authors: Clara Mathieu, François Maccari, Jean-Luc Perrot, Ziad Reguiai, Claire Boulard, Pierre-André Becherel, Anne-Claire Fougerousse, Laure Mery-Bossard, Domitille Thomas-Beaulieu, Diane Pourchot, Claire Poreaux, Charlotte Fite, Ines Zaraa, Edouard Begon, Anne-Laure Liegeon, Caroline Jacobzone, Charline Garcia, Charlotte Lepelley Dupont, Daphné Denis, Matthieu Levavasseur, Anne-Claire Bing, Anne-Sophie Dillies, Alexandra Patchinsky, Rima Mohty, Dalila Simonian, Josiane Parier, Guillaume Chaby
Institutions: Centre Hospitalier Universitaire Amiens-Picardie, Hôpital d'Instruction des Armées Bégin, Centre Hospitalier Universitaire de Saint-Étienne, Centre Hospitalier Intercommunal de Poissy, Hôpital Paris Saint-Joseph, Centre Hospitalier Régional de Metz-Thionville, Centre Hospitalier de Bretagne Sud, Centre hospitalier Emile Roux, Centre Hospitalier Annecy Genevois
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,725
OpenAlex ID: W4415722801