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Clinical characteristics and viral kinetics of DENV-1 and DENV-4 congenital dengue in two newborns

Year: 2025

Type: article

Abstract: The cases reported the clinical characteristics and viral kinetics of DENV-1 and DENV-4 in two cases of congenital dengue. We describe two neonates bom to mothers with recent dengue infections, highlighting their clinical presentation, serological progression and outcomes. Both neonates had early onset of symptoms, with one tested positive for DENV-4 and the other for DENV-1. Both experienced thrombocytopaenia without signs of haemoconcentration and recovered uneventfully. Congenital dengue, although rare, should be considered in neonates with fever and other suggestive symptoms in dengue-endemic areas. The two reported cases are unique in that both had congenital dengue fever with different serotypes, yet demonstrated prolonged NS1 antigen positivity and delayed seroconversion.

Source: Journal of Vector Borne Diseases

DOI: 10.4103/jvbd.jvbd_194_25

Authors: Chuin-Hen Liew, Gunasundari A/P Sibalinggam, David Ng Chun-Ern

Institutions: Ministry of Health, Universiti Putra Malaysia, Hospital Tuanku Ja’afar

Language: English

Topic: Mosquito-borne diseases and control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415727705

FWCI:

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