Work

Clinical Relevance of Circulating Myeloma Cell Quantification and Multiple Myeloma Staging System

Year: 2025

Type: article

Abstract: Introduction: Multiple myeloma (MM) is a clonal plasma cell malignancy primarily localized in the bone marrow (BM) and requires continuous disease monitoring due to frequent relapse. However, BM biopsy, the current diagnostic standard, is invasive and unsuitable for repeated assessment. This study evaluated the feasibility of a novel, non-invasive approach for quantifying circulating myeloma cells (CMCs) in peripheral blood (PB) using CytoGen’s Smart Biopsy platform. Additionally, it was assessed the clinical relevance between CMC counts and disease staging based on the International Staging System (ISS).

Source: The Journal of Liquid Biopsy

DOI: 10.1016/j.jlb.2025.100429

Authors: Jihyun Lee, Hyeryeong Jun, Soee Kim, Hyeonji Cho, Kihyun Kim, Jung Won Kim

Institution: Samsung Medical Center

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,080