Influence of gestational history on neural tube defects and Eisenmenger syndrome: associations with intellectual disability and visual impairment in children and adults – a systematic review
Year: 2025
Type: review
Study design: Systematic Review
Abstract: The period between conception and childbirth is known as gestational time. The condition of the baby can be affected by processes involved in pregnancy and delivery. History of diabetes and obesity during pregnancy has been proven to increase the risk of Eisenmenger Syndrome and Neural Tube Defect. Eisenmenger Syndrome is a congenital heart anomaly. Congenital heart disease, leading to circulation problems, includes issues with the iris stromal blood vessels, a characteristic feature of Eisenmenger syndrome. The dilation of iris stromal blood vessels due to this issue may lead to visual impairment/disorders. Additionally, individuals with Down syndrome and other forms of mental disorders suffer from congenital heart diseases. To analyze the influence of gestational history on the occurrence of neural tube defects and Eisenmenger syndrome, accompanied by intellectual disability and visual impairment in children and adults. A systematic review in this study was constructed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) technique. This approach ensures that all stages and research procedures are systematically followed. A total of 2,327 results were obtained after collecting sources from Google Scholar and articles published between 2018 and 2023 were filtered with defined inclusion and exclusion criteria to ensure appropriate study selection. The classification of the number of Scopus-indexed journals is as follows: the number of Q2 Scopus-indexed journals is 5, with a total of five journals taken and used as references for systematic observational research. Gestational history significantly influences the occurrence of neural tube defects and Eisenmenger syndrome, accompanied by intellectual disability and visual impairment in children and adults.
Source: Frontiers in Pediatrics
Authors: Dianasari, Chamelia Rohadatul ‘Aissy, R. Mohamad Javier, Gabriela Nativity, Syarif Syamsi Ahyandi, Siti Hani Amiralevi, Faisal Gani Putra Arlond, Khomariyana Purnama Sari, Mohammad Reza Riandata, Crysciando Jefryco Putra, Christopher Bryant Prathama, Fellicia Raphaela Thiono, Januar Ishak Hutasoit, Didik Setiyadi, Aflah Al Faiyq, Andika Prasetyo Arifin, Bernadetha Kusuma Kris Firmantya Tei Seran, David Panahatan, Muhammad Abni Setiawan, Fairuz Rifani, Afif Ferdian, Kenty Regina, Dania, Fatih Farabi, Georaldhy Yussufy Caecarma, Jonathan Alvin Wiryaputra, Auliya Yudia Yasyfin, M. Izdad Irfani Fanada, Laksmitha Saktiono Safitri, Chabib Fachry Albab, Basyar Adnani, Muhammad Rizky Hidayat, Maghfira Dwivani Rahmaputri, Trivena Sutarsa, Leony Octavia, Meliani Fransiska Andita, Harsya Parma Phastika, Johannes Tanaka, Dewi Sekarsari, Dita Ayu Dewi Laras Sati, Musthofa Chandra Ramabuana, Rilianda Simbolon, M. Rizki Fazrian Danu, Aulia Rachman, Fachira Rachel Agfata, Stefany Palyama, Andra Purwanto Yogatama Putra, Abraham Emzura Mamanta Sitepu, Restiko Maleo Fibullah, Adistia Maulidiah, Aulia Syifa, Subandono Bambang Indrasto, Abdul Alim, Renan Sukmawan, Rachmanto, Anastasia Asylia, Hayatun Nufus, Pertiwi Febriana Chandrawati, Aan Dwi Prasetyo, Lucky Sutanto, Moch. Aleq Sander
Institutions: Sebelas Maret University, Rumah Sakit Dokter Soetomo, Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, Universitas Kristen Indonesia, Rumah Sakit Umum Haji Surabaya, Ciliwung Merdeka, Pusat Mata Nasional Rumah Sakit Mata Cicendo, Universitas Airlangga, RSUD Prof. Dr. Margono Soekarjo, Padjadjaran University, Tarumanagara University, Pertamina (Indonesia), Gatot Soebroto Army Hospital, Rumah Sakit Umum Pusat Dr. Sardjito, Universitas Muhammadiyah Malang
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funder: Universitas Indonesia
OpenAlex ID: W4416729508