Maternal Myo‐Inositol Intake and Congenital Heart Defects in Offspring: A Population‐Based Case–Control Study
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To investigate associations between maternal periconceptional (three months prior through the third pregnancy month) myo-inositol intake and the odds of selected congenital heart defects in offspring. DESIGN: A population-based case-control study using the National Birth Defects Prevention Study (NBDPS) database. SETTING: United States. POPULATION OR SAMPLE: Women with singleton live births without major birth defects (controls) and women with singleton live births, stillbirths, or terminations with selected nonsyndromic congenital heart defects (CHD; cases). METHODS: Descriptive analyses, logistic regression models, ascertainment of myo-inositol intake from supplements and food using a shortened food frequency questionnaire and survey. MAIN OUTCOME MEASURES: Odds of CHD. RESULTS: 11 752 cases and 11 415 controls were included. Compared to women not taking myo-inositol supplements, women with any supplemental intake were less likely to have a pregnancy with the selected congenital heart defects as a group (adjusted odds ratio [aOR] = 0.79; 95% confidence interval [CI] 0.66-0.94) or with septal defects alone (aOR = 0.61; 95% CI 0.46-0.81). Compared to women with low total myo-inositol intake from food or supplements, women with high total myo-inositol intake (≥ 500 mg/day) were less likely to have a pregnancy with the selected CHD as a group (aOR = 0.88; 95% CI 0.84-0.93) or conotruncal defects (aOR = 0.87; 95% CI 0.79-0.96); left ventricular outflow tract defects (aOR = 0.87; 95% CI 0.78-0.96); right ventricular outflow tract defects (aOR = 0.85; 95% CI 0.77-0.95); or atrial septal defects (aOR = 0.91; 95% CI 0.83-0.99). CONCLUSIONS: An inverse association was observed between maternal myo-inositol intake during the periconceptional period and the odds of selected CHDs in offspring.
Authors: Ruiqi Cen, L. Joseph Su, Jun Ying, Mohammed S. Orloff, Elijah H. Bolin, Xiangyang Lou, Lynn M. Almli, Lorenzo D. Botto, Marilyn L. Browne, Richard H. Finnell, Mary M. Jenkins, Eirini Nestoridi, Andrew F. Olshan, Paul A. Romitti, Gary M. Shaw, Wendy N. Nembhard, the National Birth Defects Prevention Study
Institutions: University of Arkansas for Medical Sciences, The University of Texas Southwestern Medical Center, University of Colorado Anschutz, University of Colorado Denver, Arkansas Children's Hospital, University of Florida Health, University of Florida, Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, University of Utah, New York State Department of Health, University at Albany, State University of New York, Baylor College of Medicine, Massachusetts Department of Public Health, University of North Carolina at Chapel Hill, University of Iowa, Stanford Medicine, Stanford University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
OpenAlex ID: W4416758809