Supplementary Figure S5 from A First-in-Class mAb (BI-1607) Targeting FcγRIIB: Preclinical Data and First-in-Human Studies in Patients with HER2-Positive Advanced Solid Tumors
Year: 2025
Type: supplementary-materials
Abstract: Figure S5: Cytokine release in high density cell culture. 1x105 PBMCs resuspended in fresh serum free CTL-Test media were stimulated with 10 μg/mL antibody added in solution to the cells for 24 hours at 37°C in 5% CO2. The cytokine levels in the culture supernatant were measured using a 7-plex customized MSD plate. A paired one-way ANOVA with Tukey’s multiple comparison was used to determine significance; * = p<0.05; ns = not significant. Lines indicate mean values for each cytokine; each dot is indicative of an individual healthy donor (n=6).
Authors: Javier Cortés, Araceli Priego, Elena Garralda, Katerin Rojas, Simon R. Lord, Thorsten O. Goetze, Sherko Kuemmel, Simon J. Crabb, Zinnia P. Parra-Guillen, Marie Borggren, Ingrid Karlsson, Danijela Lindahl, Linda Mårtensson, Robert Oldham, Anna Ropenga, Ingrid Teige, Johan Wallin, Björn Frendeus, Andres McAllister
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4416844628