The effect of Beta - aminobutyric acid on Malondialdehyde and urea levels in type 2 diabetic male rats
Year: 2025
Type: article
Abstract: Diabetes mellitus, a complex metabolic disorder characterized by hyperglycemia. Objective: This study aimed to evaluate the protective effect of beta-aminobutyric acid (BABA) on streptozotocin (STZ)-induced diabetes in male rats, by studying its effect on Malondialdehyde (MDA), and urea. Thirty adult male albino rats models of diabetes mellitus were randomly assigned to six groups of five pets each, age of (8-10 weeks). All rats were in good health, with weights ranging from 140 to 160 grams, Positive control groups treated with normal saline, Negative control groups treated only with streptozotocin, Group A treated with 50 mg/kg of STZ then BABA, Group B treated with 100 mg/kg strptozotocin then BABA, Group C treated with 150 mg/kg of strptozotocin then BABA, and Group D treated with 200 mg/kg of strptozotocin then BABA. Enzyme-linked immunosorbent assay (ELISA) was utilized to evaluate MDA, and urea levels in serum. The results of the study show MDA levels elevated in the rats studied (Control -,A, B, C, and D) which recorded (4.47 ±1.93 mg/dl), (3.01 ±0.76 mg/dl), (3.07 ±0.41 mg/dl), and (2.04 ±0.22 mg/dl), compared control group(4.61 ±0.15 mg/dl), results indicate high levels of urea in the groups of rats studied (Control -,A, B, C, and D) which recorded (115.33± 39.01) mg/dl, (107.67±22.25)mg/dl, (70.67±22.06)mg/dl, (73.00±13.65)mg/dl, and (57.67±3.71) mg/dl, compared to control+ (44.33±3.48)mg/dl. The results indicated correlation coefficient between weight and sugar Level is 0.027. This indicates a very weak positive correlation between the two variables, that there is no significant linear relationship between weight and sugar level in rats studied. BABA plays an important protective role as an antioxidant against STZ-induced oxidative stress.
Institution: University of Anbar
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416873159