Endometriose, autoimunidade tireoidiana e reserva ovariana: nota de pesquisa
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objectives: to assess ovarian reserve in women with endometriosis according to the presence of antithyroid antibodies. Methods: retrospective cross-sectional study conducted in assisted reproduction clinics in Recife, Brazil, from February 2017 to August 2021. Women aged 18-49 years with endometriosis and recorded measurements of anti-TPO and/or anti-Tg, anti-Müllerian hormone (AMH), and antral follicle count (AFC) were included. Women with other causes of diminished ovarian reserve were excluded. Numerical variables were compared using the Mann-Whitney test, with p<0.05 considered significant. Results: of 83 eligible women, 48 were analyzed: 14 (29.2%) antibody-positive and 34 (70.8%) negative. Age and body mass index were similar between groups. No significant differences were found in TSH or free T4 levels. Median AMH was 0.66 ng/mL in the positive group and 1.37 ng/mL in the negative group (p=0.09), and AFC was 7.5 vs. 10.0, respectively (p=0.41). Conclusions: among women with endometriosis, a high prevalence of thyroid autoantibodies was observed. There were no statistically significant differences in ovarian reserve markers between groups, although a trend toward lower AMH values was seen among antibody-positive participants. Future studies with larger samples may confirm or modify these findings.
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4417044907