Work

FAM134B controls collagen I dynamics in hepatic stellate cell-driven fibrosis

Year: 2025

Type: article

Abstract: We show for the first time that TGFβ-mediated activation of HSCs induces selective autophagy of the endoplasmic reticulum (ER-phagy), through upregulation of ER-phagy receptors and ER-phagic flux. We further show that the unfolded protein response is critical for this effect. Finally, we identify the ER-phagy receptor FAM134B as a critical regulator of collagen I dynamics and fibrogenesis, with loss of FAM134B dysregulating collagen I secretion and deposition.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00170.2025

Authors: Jagannath Misra, Zachary Hanquier, Reese Baxter, Nipuni Barupala, Alexander Jackson, Jessica L. Maiers

Institutions: Indiana University School of Medicine, Indiana University Indianapolis

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases