Year: 2025
Type: article
Abstract: In the world, more than 2 billion people are overweight, which makes up 30-39% of the world’s population. Against the background of existing obesity, comorbid pathology is progressing in patients. The article provides information on the pathogenetic basis of obesity. The features of functioning and hormonal activity of adipocytes are described. The mechanisms of the effect of hormones and metabolically active substances produced by adipocytes on the human body, the development of comorbid pathology are considered. all of them have been studied in detail. Based on the analysis, it can be assumed that unexplored metabolites secreted by adipose tissue may play a key role in the regulation of metabolism, inflammatory processes and even in the development of various diseases, including obesity. The low effectiveness of obesity treatment, despite financial costs exceeding 2 trillion US dollars annually, actualizes the revision of existing approaches, the development of new treatment methods and medicines based on a deeper understanding of the pathogenetic foundations of obesity.
Source: Obesity and metabolism
DOI: 10.14341/omet13149
Authors: V. V. Shishkina, A. A. Glukhov, A. A. Andreev, N. S. Kovalenko, M. V. Eliseev, A. Yu. Laptiyova, A. P. Ostroushko, A. Yu. Frolov
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4417201007