Genomic Determinants of Immune Variation: Epidemiologic Perspectives on Mechanisms and Clinical Translation
Year: 2025
Type: article
Abstract: Advances in genomics and immunology have redefined the understanding of immune regulation, disease susceptibility and therapeutic response. This review synthesizes evidence across multiple biological scales—including germline variation, somatic mutations, epigenomic architecture and single-cell immune heterogeneity—to elucidate how genomic mechanisms shape immune function in health and disease. Emphasis is placed on the translational relevance of these mechanisms, particularly in the context of cancer immunotherapy, autoimmune risk stratification and emerging engineered-immunity platforms such as CRISPR-based editing and CAR T-cell therapies. The analysis also highlights the persistent underrepresentation of populations from Mexico, Colombia and Ecuador in genomic datasets, underscoring the need for inclusive precision-medicine strategies. By integrating mechanistic, technological and clinical dimensions, this review outlines the conceptual foundations of immunogenomics and identifies the opportunities and challenges that will shape its evolution as a global, population-relevant discipline.
Source: International Science Journal
DOI: 10.64784/067
Authors: Ángela Patricia López Alvarado, José Enrique González Araujo, Stephanie Mora López, Alan Chavez Rubio, Jorge Angel Velasco Espinal, Daniel Alberto Madrid González, Zaulo Emmanuel Alcaraz Hernández, Jorge Luis Jimenez Loza
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4417285397