Year: 2025
Type: article
Abstract: Mass spectrometry imaging (MSI) visualizes the spatial distribution of biomolecules in tissues, whereas ion mobility-mass spectrometry (IM-MS) separates ions through the collision cross-section (CCS) with an inert gas, providing the structural characteristics of isomers. Recent advances have established an integrated workflow, ion mobility-mass spectrometry imaging (IM-MSI), that couples IM with MSI, uniting molecular discrimination with spatial mapping. This synergy has been widely applied in oncology and neuropsychiatric disorders, offering unprecedented insights into biomarker discovery and disease mechanisms. Here, we summarize the principles and classifications of IM-MSI, review their combined biomedical applications, and discuss data processing workflows and commonly used tools.
Source: BioTech
Institutions: Hamamatsu University, Hamamatsu University School of Medicine
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,930
Awards: G2367363754, G3068123399, 質量顕微鏡による分子情報イメージング, FLASH放射線療法における脂質の細胞・臓器レベルでの役割解明と新規脂質ペプチド治療法の開発, G6184921693, G8456702549, The elucidation of the anatomical mechanism of exosome classification factor UBL3 in the spatial propagation of brain proteins, Study of Propagation Pathology through Wide-field Mass Spectrometry Imaging Using a Generative AI Model
OpenAlex ID: W4417455177