Year: 2025
Type: article
Abstract: The functioning of the human genome plays a role in protecting the body from viral invasion. The body’s susceptibility to various viral diseases is determined not only by the functioning of the innate and adaptive immune systems but also by individual genomic differences. Mutations in the FUT2 gene region can exert a protective effect against norovirus gastroenteritis, but also increase the risk of developing and complicating other diseases. The molecular mechanism of interaction between OAS family genes and the innate immune system, as well as the characteristics of normal genomic polymorphism, influence the development and favorable outcome of viral diseases. An analysis of information sources on the relationship between genomic processes and the course and outcome of viral diseases, as well as individual aspects of the influence of disease characteristics on these processes, was conducted as of July 2025. The following keywords were used in key electronic databases, including PubMed, Scopus, eLIBRARY, and Google Scholar: FUT, OAS, HDAC, epigenetics, immune resistance, viral diseases, and host immunity. Several mechanisms of the influence of epigenetic processes on the course of diseases, as well as the possibilities for their therapeutic correction, are presented. Research into the fundamental aspects of the influence of genetic control mechanisms on susceptibility to viral infections will allow for new understanding of risk groups and mechanisms for disease prevention and treatment.
Source: Journal Infectology
Authors: D. A. Verbenko, V. A. Belyaev, A. E. Panova, M. A. Vashukova, A. V. Semenov
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4417465129