Work

Comparative Histology of the Swine Colon Raised under Intensive Management Farming and Backyard Farming Systems in Thailand

Year: 2025

Type: article

Abstract: Swine farming methods can influence gut health by altering intestinal morphology and immune function. This study aimed to compare the histological characteristics of the colon in swine raised under 2 different management systems - intensive management farming and backyard farming - to evaluate how these environments impact intestinal structure and health. Colon tissues (n = 10 per group) were collected and examined using Hematoxylin and Eosin staining. Histological analysis focused on the thickness of the mucosa, submucosa, and muscularis externa layers, the morphology of intestinal glands, and the presence of inflammatory cells and lymphatic nodules in the mucosa. The results showed that swine raised under intensive management farming had significantly thicker mucosal, submucosal, and muscularis externa layers than those raised under backyard conditions (p < 0.001). Backyard-farmed swine exhibited significantly shallower and narrower intestinal glands, as well as reduced numbers of inflammatory cells and lymphatic nodules (p < 0.001), suggesting a lower degree of immune activation. In conclusion, our findings suggest that intensive management enhances nutrient absorption and mucosal defense via a thicker colonic mucosa, whereas backyard farming may impair digestive efficiency and immune responsiveness. By linking husbandry conditions to intestinal histology, this study provides clinically relevant insights into how farming systems influence swine gut health which may ultimately impact overall productivity and product quality. These results underscore the importance of appropriate farm management in supporting gastrointestinal and immune function in livestock. HIGHLIGHTS Histological analysis revealed significant differences in colon structure between swine raised under intensive management farming and backyard farming in Thailand. Swine raised under intensive management farming showed significantly thicker mucosa, submucosa, and muscularis externa layers. Backyard-farmed swine exhibited shallower and narrower intestinal glands with reduced inflammatory cells and lymphatic nodules. Farming method influences gut morphology and immune response in swine, suggesting a link between husbandry conditions and intestinal health. Thinner mucosal layers and reduced immune activity in backyard swine may impact nutrient absorption and disease resistance. Our study provides the first comparative histological evidence linking farming systems to intestinal morphology and immune profiles in swine. GRAPHICAL ABSTRACT

Source: Trends in Sciences

DOI: 10.48048/tis.2026.11188

Authors: Jarinthorn Teerapornpuntakit, Saimai Chatree, Kittipong Limpatchayopas, Jenjira Chamta, Arnaud Monteil, Charkriya Promsuban