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EFFECT OF VITAMIN C TREATMENT ON SERUM PROTEIN, ALBUMIN, BETA-GLOBULIN PROFILES AND BODY WEIGHT OF Trypanosoma brucei-INFECTED Rattus norvegicus

Year: 2016

Type: article

Abstract: The effect of vitamin C supplements on serum protein profile and body weight of Trypanosoma brucei-infected rats was investigated. The rats were inoculated with trypanosomes intraperitoneally and samples were collected on fourth, eight, twelfth and sixteenth days of post infection (pi). Sixty (60) parasite free-albino rats were used, which were divided into four groups. Group A (control) was left uninfected with trypanosomes, group B and C were infected with Trypanosomes and treated with 40mls and 60mls of ascorbic acid (Vitamin C), respectively. Trypanosoma brucei infection caused significant (p<0.01) decreases in serum total proteins, albumin, beta globulin and body weight levels in untreated rats. Consumption of Vitamin C, however, prevented these disease-induced anomalies in the treated infected rats. Analyses of the sera using Bradford method and cellulose acetate electrophoresis showed that Vitamin C infected the state of serum protein, albumin and gamma globulin in the trypanosome-infected treated rats. It was concluded that consumption of the Vitamin C ameliorated the pathological changes in serum protein and body weight of T. brucei – infected rats.

Source: Animal Research International

Authors: Cyril Onyekachi Edoga, Oliver O. Njoku, John Johnson Okeke, C. E. Ani

Institutions: University of Nigeria, Federal University of Technology Owerri, Nnamdi Azikiwe University, Ebonyi State University

Language: English

Topic: Trypanosoma species research and implications

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W53665580

FWCI:

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Cited by: 4

Related to: 10