Age-Disparate Partnerships and Risk of HIV-1 Acquisition Among South African Women Participating in the VOICE Trial
Year: 2015
Type: article
Abstract: A recent analysis from South Africa reported no association between age-disparate relationships and HIV-1 acquisition. We assessed the association between male partner age and HIV-1 acquisition among South African women participating in the VOICE trial. Of 4077 women enrolled, 3789 had complete data; 26% and 5% reported having a partner >5 and >10 years older at enrollment, respectively. Reporting a partner >5 years older (hazard ratio = 1.00; 95% confidence interval: 0.74 to 1.35) or >10 older (hazard ratio = 0.92; 95% confidence interval: 0.49 to 1.74) was not associated with HIV-1 acquisition. These data corroborate recent reports and may suggest a shift in local epidemiology of heterosexual HIV-1 transmission.
Institutions: South African Medical Research Council, University of the Witwatersrand, University of Washington, Chris Hani Baragwanath Hospital, Fred Hutch Cancer Center, University of KwaZulu-Natal, Centre for the AIDS Programme of Research in South Africa, RTI International, Aurum Institute, University of California, San Francisco, University of Zimbabwe-University of California San Francisco
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Statistical and Data Management Center (SDMC): Microbicide Trials Network, Leadership and Operations Center (LOC): Microbicide Trials Network, South African Medical Research Council Clinical Trials Unit (MRC CTU), Laboratory Center (LC): Microbicide Trials Network, UZ-UCSF CTU, Wits HIV Research Group CLINICAL TRIAL UNIT (CTU) reapplication, PHRU-Setshaba Clinical Trials Unit
OpenAlex ID: W601003251