Involvement of Spinal Ca^<2+> Channels and Intracellular Signal Transducing System in Nitrous Oxide-induced Analgesia
Year: 2000
Type: article
Abstract: Nitrous oxide ( N20 ) has a potent antirlociceptive action ， ↑he spinal Ca2 ＋ channel and the intracel且ular signal transducing system have recently been suggestedto play an important role in pain transmission and modulation ， The present study was undertaken to evaluate further the involvement of the Ca2 ＋ channels and the intracellular signal transducing system activity in N20 analgesia by investigating tail -flick latency and in vitto autoradiography ． Wister rats were exposed to either 70 ％ N2 ( contro1 ) or 70 ％ N20 with 30 ％ 02 for 2 hours after staying 30 minutes in plastic box ． N20 produced arlalgesia ： the percent maximal effect ( ％ MPE ； tail -flick latency ) increased to 79 ％ at 30 minutes after starting of N ，O inhalation ． At the end of N20 exposure ， 1251 一 ω CgTx binding ( N type Ca2 ＋ channel activity ) in the spiral cord ( Rexed I -H ) decreased by 20 ％ accompanied by a decreased in 3H -forskolin binding ( adenylate cyclase ： 22 ％ ) ， while 3H -PN 200 -110 binding ( L type Ca2 ＋ channel activity ) and 3H -GTP binding ( G -prote 正 n ) did not changed ． These results suggest that the interactions with N type Ca2 ＋ channel and adenylate cyclase in the dorsal horn of the spiral cord are involved in analgesia induced by N ，O inhalation ，
DOI: 10.2504/kds.54.305
Author: Shiro Kasai
Institutions: Kyushu University, Kyushu Dental University
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W614598140