Work

Interstitial pneumonia and de-novo onset of asthma induced by leuprorelin acetate for prostate cancer

Year: 2006

Type: article

Abstract: We describe herein the first report of side effects induced by leuprorelin acetate (LA) administration. A 70-year-old man, with idiopathic pulmonary fibrosis (IPF), vasospastic angina, diabetes mellitus type 2, and arteriosclerosis obliterans was suffering from prostate cancer. LA administration (drug-) induced interstitial pneumonia based on IPF and the de-novo onset of bronchial asthma, both of which are thought to be Th 2-related diseases. Using 3-color flow cytometry, we analyzed the chemokine receptors CD4+CXCR3+/CD3+ and CD4+CCR4+/CD3+, and found that the CXCR3/CCR4 ratio changed in the Th 2 pattern. It is important to be careful with LA administration, especially for underlying Th 2-related diseases, and clinicians should fully understand the possibilities of LA-inducing de-novo Th 1/Th 2-driven autoimmune diseases.

Source: Institutional Repositories DataBase (IRDB)

Authors: Hidetomo Yamasaki, Hideto Nakajima, Toshifumi Tanaka, Nakaaki Ohsawa

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W653331237

FWCI:

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