Multi-scale modelling of heat and mass transfer in tissues and cells during cryopreservation including interval methods
Year: 2023
Type: dissertation
Abstract: This thesis is devoted to large-scale modelling of the coupled phenomena that occur during cryopreservation.This is a process that involves slowing down the activity of biological material by lowering the temperature below physiological temperature and then restoring the function of the cryopreserved tissues or cells, while preserving their basic vital activities.In order to avoid the negative effects of the process, chemical compounds called cryoprotectants and regulation of the cooling rate are used.This paper presents examples of cryopreservation methods such as slow freezing, vitrification and the "liquidus tracking" protocol.Transport phenomena such as heat transfer with crystallisation, mass transfer in the context of mass diffusion and fluid flow, and osmotic
Author: Skorupa, Anna
Language: English
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6993003100