AVATAR: A database for genome-wide alternative splicing event detection through analysis of large scale ESTs and mRNAs
Year: 2005
Type: article
Abstract: UNLABELLED: In the past years, identification of alternative splicing (AS) variants has been gaining momentum. We developed AVATAR, a database for documenting AS using 5,469,433 human EST sequences and 26,159 human mRNA sequences. AVATAR contains 12000 alternative splicing sites identified by mapping ESTs and mRNAs with the whole human genome sequence. AVATAR also contains AS information for 6 eukaryotes. We mapped EST alignment information into a graph model where exons and introns are represented with vertices and edges, respectively. AVATAR can be queried using, (1) gene names, (2) number of identified AS events in a gene, (3) minimal number of ESTs supporting a splicing site, etc. as search parameters. The system provides visualized AS information for queried genes. AVAILABILITY: The database is available for free at http://avatar.iecs.fcu.edu.tw/
Source: Bioinformation
Authors: Fang Rong Hsu, Hwan-You Chang, Yaw-Lin Lin, Yin-Te Tsai, Hui-Ling Peng, Ying Tsong Chen, Chia Yang Cheng, Min Yao Shih, Chia-Hung Liu, Chin-Feng Chen
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Funder: National Science Council
OpenAlex ID: W70305554