Training programmes in countries overseas should be supported
Year: 1996
Type: letter
Abstract: FceRI-P polymorphisms unlikely to contribute substantially to genetic risk of allergic disease EDITOR,-M R Hill and colleagues report the association between a variant of the gene for the 1B chain of the high affinity receptor for IgE (FCeRI-O) with the Leu 181/Leu 183 polymorphism and atopy in an Australian population.'They suggest that polymorphism in FcsRI-is one factor that can be used to assign genetic risk of atopy.This group has previously suggested that Leu 181 may be associated with atopy in the British population.2As part ofa study examining the relation between 12 adrenoceptor polymorphisms and airway reactivity3 we recently screened a population of asthmatic patients for FcERI-3 polymorphisms.Polymerase chain reaction based on the amplification refractory mutation system failed to identify any subjects with either the Leu 181 or the Leu 181/ Leu 183 polymorphism.We therefore proceeded to direct sequencing of this region of FcsRI-to ensure that our ability to detect the Leu 181 polymorphism was not due to problems with the method.None of our 65 asthmatic subjects, however, had either the Leu 181 or the Leu 183 substitution on direct sequencing.Of these 65 subjects, 41 fulfilled Hill and colleagues' criteria for atopy, although all had a 20% fall in forced expiratory volume in one second after challenge with methacholine.These results suggest that, while FcsRI-P polymorphisms may contribute to the atopic phenotype in defined populations, they are unlikely to contribute substantially to the genetic risk of allergic disease in the population at large.
Source: BMJ
Authors: J Brian Coulter, John Cox, Tim Goodacre, Neville Harrison, Angela Hilton, George Griffin, John Guy, Anthony Jefferies, Nigel Leigh, Adrian Marston, Chris Milford, Eldryd Parry, Peter Poore, John Rennie, Bernard Ribeiro, Terance Ryan, Patrick Sissons, Richard Southwell, Ian Todd
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W70404091