Determination of azelaic acid in pharmaceuticals and cosmetics by RP-HPLC after pre-column derivatization.
Year: 1994
Type: article
Abstract: This paper reports a RP-HPLC method for the determination in topics of azelaic acid, a keratolytic and anti-comedogenic agent widely used in the treatment of all types of acne. A derivatization step was needed prior to chromatographic analysis because the analyte is lacking in chromophore. A sample clean-up procedure by solid-phase extraction was also developed to analyse azelaic acid in complex matrices, such as pharmaceutical and cosmetic formulations.
Source: PubMed
Authors: V Ferioli, C Rustichelli, F Vezzalini, G Gamberini
Institution: University of Modena and Reggio Emilia
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W70479804