Senolytic Treatment With Dasatinib and Quercetin Reshapes Influenza‐Specific CD8 T Cell Responses During Infection in Aged, Vaccinated Mice
Year: 2025
Type: article
Abstract: Older adults are disproportionately affected by infectious diseases like influenza (flu) due to immune declines and poor vaccine responses. Senolytics have been shown to improve various age-related conditions and positively influence infection outcomes, yet their potential to enhance vaccine responses has not yet been explored. Here, we evaluated the potential of senolytic combination Dasatinib (D) and Quercetin (Q) treatment prior to influenza vaccination to potentiate immune responses in aged mice. D + Q had minimal impact on overall vaccination and flu outcomes in vaccinated mice, including viral load and lung pathology. However, we observed altered CD8 T cell immunodominance and increased serum total PR8 (whole flu) IgG antibodies in D + Q treated vaccinated aged mice during infection. These findings reveal a new aspect of immunomodulation with senolytics.
Source: Aging Cell
DOI: 10.1111/acel.70345
Institutions: University of Connecticut, UConn Health
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,790
Awards: G2354209684, G8568292425, Impact of Senolytics on Aged Vaccine Responses, Regenerative Engineering of Musculoskeletal Tissues- a Convergence Doctoral Training Program, Claude D. Pepper Older Americans Independence Center (P30 Clinical Trial Optional), Undergraduate Fundamentals in Aging Research
OpenAlex ID: W7117547592