1.1. What Drives Variability in Salivary Progesterone among Males?: An Exploratory Study in Outpatients with Cannabis Use Disorder
Year: 2025
Type: preprint
Abstract: Variables that influence salivary progesterone (P4) measurement accuracy, daily levels, and day-to-day variability in males remain understudied, despite evidence that multiple factors impact male sex hormones. Prior work indicates that biological factors, such as diurnal rhythms, interhormonal interactions, body composition, ethnicity, age, and health history likely contribute to variation in male sex hormone levels. In addition, medication use and substance intake along with social factors such as relationship and fatherhood status may introduce between and within-person variability in sex hormones. The purpose of this study is to assess environmental, assay-related, and biological correlates of (1) mean salivary P4 level per person and (2) P4 variability (defined as the per-person standard deviation of P4 levels) in males across an eight week study. These analyses will lay the groundwork for identifying which factors to consider when designing studies and interpreting salivary P4 data, particularly in male samples.
Source: OSF Preprints (OSF Preprints)
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7117883232