Synopsis: Current Trends in the Management of Acute Chest Syndrome in Children with Sickle Cell Disease
Year: 2026
Type: article
Abstract: Acute chest syndrome (ACS) is one of the most serious and frequent pulmonary complications of sickle cell disease in childhood. Defined by the presence of a new pulmonary infiltrate on chest imaging accompanied by fever and/or respiratory symptoms. The clinical manifestation of ACS ranges from a mild, self-limited illness to fulminant respiratory failure requiring intensive care and life-saving interventions. Acute chest syndrome is one of the leading causes of hospitalization and a major contributor to morbidity and mortality in children with sickle cell disease (SCD). Early recognition and prompt institution of evidence-based management strategies are therefore essential to reduce the immediate complications and long-term pulmonary sequelae of the disease. This review discusses current trends in the management of ACS in children with SCD, as well as practical approaches to ACS management in resource-poor settings.
Source: Nigerian Journal of Paediatrics
Language: English
Subfield: Genetics (clinical)
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7125970592