Voltammetric sensor based on zeolitic imidazolate framework ZIF-8 for Voltammetric sensor based on zeolite-like imidazolate framework ZIF-8 for determining tramadol
Year: 2025
Type: article
Abstract: A planar electrochemical sensor based on a screen-printed carbon electrode (SPE) modified with a zeolite-like imidazolate metal-organic framework ZIF8 and graphene was developed for determination of the synthetic analgesic tramadol using linear sweep voltammetry. Modification of the electrode with a nanocomposite modifier increased its surface by 1.6 times and aided in a three-fold increase in the peak current of tramadol oxidation. It was shown that the highest tramadol oxidation current was recorded at 10 % ZIF8 in the nanocomposite modifier and using a phosphate buffer solution with pH 7 as a background electrolyte. A shift in the potential of the tramadol oxidation peak by 130 mV to the lower values was observed on the modified electrode compared to the unmodified one. It was found that tramadol electrooxidation on graphene-ZIF8/SPE is an irreversible adsorption-controlled process involving one electron. The parameters of tramadol electrooxidation were calculated and a scheme of the electrode reaction proposed. The detection limit of tramadol and the linear range of the sensor are 0.01 μM and 0.25–1800 μM, respectively. The sensor exhibits high selectivity for a number of compounds accompanying tramadol in real samples, which allows its use in the analysis of artificial blood serum and pharmaceuticals in the form of tablets and injection solution. The correctness factor of 96–105 % proves the absence of a systematic error in tramadol determination; and the relative standard deviation not exceeding 5 % indicates good repeatability of the analytical results. The absence of additional separation and concentration stages makes the analysis using graphene-ZIF8/SPE highly expressive.
Source: Analitika i kontrolʹ
Institution: Ural State University of Economics
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W7126380692