Work

The role of human adipose-derived mesenchymal stem cell-derived exosomes in burn injury: a narrative review

Year: 2026

Type: review

Abstract: Burn injuries constitute a significant global health concern, presenting both health hazards and economic challenges. Recently, human adipose-derived mesenchymal stem cell exosomes (hADSCs-Exo) have emerged as a cell-free therapeutic strategy for promoting burn wound healing. These nano-sized particles function through various mechanisms, including promoting cellular migration, angiogenesis, inflammation reduction, immune response modulation, collagen remodeling, and scar prevention. They exert these effects by activating critical signaling pathways such as PI3K/Akt, IL-17RA/Smad, and mTOR. This review summarizes the biological characteristics and research relevance of hADSCs-Exo in burn injury management and discusses their translational implications.

Source: Frontiers in Bioengineering and Biotechnology

DOI: 10.3389/fbioe.2026.1730449

Authors: Haoran Tang, Qi Wang, Jun Xue, Liang Shen, Xiaguang Duan, Biao Zhou

Institutions: Third Affiliated Hospital of Inner Mongolia Medical College, Inner Mongolia Medical University

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801