Year: 2026
Type: article
Abstract: Micellar gels are a promising system to deliver poorly water-soluble and hydrophobic therapeutics topically. Micelles are nanoscale colloidal drug delivery carriers that improve the solubility of drugs and can deliver payloads passively or actively to target a particular tissue. Once loaded into semisolid gel, micellar gels improve drug permeation through the skin for worthy treatment against deeply-seated infections, such as fungal infections. Micellar gels can also provide sustained and localized drug release with improved bioavailability and may be a cost-effective approach to manufacture these products. Several different strategies are used to form micellar gels (dialysis, solvent evaporation, solid dispersion, microphase separation, thermal transition, chemical reaction or flocculation, etc.) There are several characterization methods (e.g., particle size, critical micellar concentration (CMC), entrapped drug efficiency, drug content, NMR, DSC, viscosity, spreadability, extrudability, skin irritation studies, ex vivo skin permeability studies, etc.) for micellar gels. All of these benefits make micellar gels and a versatile and effective delivery system for topical and localized therapeutics.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W7127044875