Association of NRF-2 changes in plasma and pericardial fluid with renal injury in patients undergoing cardiac surgery
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective: This study was conducted to investigate the levels of nuclear factor (erythroid derivative 2)-like 2 (NRF-2), kidney injury molecule 1 (KIM-1), and heme oxygenase-1 (HO-1) in pericardial fluid (PF) and systemic circulation of patients undergoing cardiac surgery.Methods: This study included 40 patients undergoing cardiac surgery and 40 healthy individuals.PF and venous blood samples were obtained from the patients and renal function tests, HO-1, KIM-1, NRF-2, antioxidant, and oxidative stress parameters were studied.Results: A statistically significant difference was found in the NRF-2, KIM-1, HO-1, total antioxidant status, total oxidant status, and oxidative stress index measurements in the plasma of the patient and control groups and in the PF of the patients (p < 0.01).Compared to the control group, NRF-2, KIM-1, and HO-1 were found to be lower in the patient's plasma and PF.In the patient group, NRF-2, KIM-1, HO-1, and KIM-1 were higher in PF compared to plasma.Conclusions: In the future, intrapericardial drug administration may improve cardiac function and prevent the adverse cardiorenal syndrome on the kidney.
Institution: Harran University
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Harran Üniversitesi
OpenAlex ID: W7127635170
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