Work

Discovery and Optimization of Orally Bioavailable Heterobifunctional Degraders of KAT2A/B for the Treatment of Cancer

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c03208

Authors: James Neef, Kimberly S. Straley, Chinmoy Mukherjee, Amol Tipnis, Suleman Riyajsaheb Maujan, Maulasri Bhatta, Sambad Sharma, Sara Sinicropi-Yao, Joe DeBartolo, Andrew J. McRiner, Betty Chan, Henry Wilson, Christina S. Lee, Zied Boudhraa, Mohamed El Ezzy, Mark Bittinger, Laura Jennings Antipov, Thomas G. Graeber, Katharine E. Yen, David S. Millan

Institutions: Industrial Credit and Investment Corporation of India, Paraza Pharma (Canada)

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W7128370445

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Cites: 27

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