Optimalisasi Gelling Agent Kombinasi Natrium Alginat dan Hydroxyprophyl Methylcellulose dalam Sediaan Gel Madu Kelulut melalui Pendekatan Factorial Design
Year: 2025
Type: article
Abstract: Kelulut honey has been traditionally and empirically used for wound healing due to its natural antibacterial, anti-inflammatory, and antioxidant properties. To enhance its applicability and effectiveness in wound care, it has been formulated into a gel dosage form by using gelling agent, like sodium alginat and hydroxypropyl methylcellulose (HPMC). The objective of this study was to formulate Kelulut honey gel using a combination of sodium alginate and (HPMC) as gelling agents. A factorial design approach was employed using Design Expert software to optimize the formulation parameters. The evaluation focused on key physicochemical characteristics such as viscosity, pH, spreadability, and adhesiveness. All formulations produced through the factorial design met the established quality requirements for topical gel preparations and good stability. Furthermore, validation between predicted and experimental values yielded a 95% prediction interval, indicating strong agreement and supporting the reliability and accuracy of the model. These results confirm the potential of the optimized Kelulut honey gel formulation for further development and application.
Source: Healthy-Mu Journal
Institutions: Universitas Muhammadiyah Banjarmasin, Universitas Gadjah Mada
Language: English
Subfield: Insect Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $16
OpenAlex ID: W7128489461