Glutathione-responsive deformable manganese-based nanomedicines for enhanced tumor-specific chemotherapy
Year: 2026
Type: article
Abstract: experiments reveal that their enhanced cellular uptake, multicellular spheroid penetration, and tumor accumulation, increased by 17.64-fold, 2.25-fold and 1.6-fold, compared to that of the stiff counterpart, respectively. Additionally, an excellent specific chemotherapy efficacy with tumor growth inhibition was realized in a mice OS model, by intravenous administration of DMNs. In conclusion, glutathione-responsive deformable manganese-based nanomedicines demonstrate clinical potential by addressing the limitations of precision manganese and dopamine delivery and achieving enhanced tumor-specific chemotherapy for osteosarcoma.
Source: RSC Advances
DOI: 10.1039/d6ra00177g
Authors: Pengcheng Li, Jun Tao, Xinzeyu Yi, Qinghui Qi, Zhou Liang, Ye Wu, Wubulitalipu Xirena, Chenxian Ye, Yunqin Ke, Lianhui Wang, Wanrong Yi
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,042
Award: G2053705869
OpenAlex ID: W7128599474