The influence of vitamin d, vitamin k, and parathyroid hormone on anemia severity in chronic kidney disease patients undergoing hemodialysis
Year: 2026
Type: article
Study design: Observational Study
Abstract: Patients undergoing hemodialysis for end-stage renal disease (ESRD) frequently have anemia.Disruptions in vitamin D and vitamin K metabolism, along with alterations in parathyroid hormone levels, may influence the severity of anemia in this population.This study investigated the impact of vitamin D, vitamin K, and parathyroid hormone (PTH) levels on the severity of patients with ESRD undergoing maintenance hemodialysis.The Hamida Al-Masfah Dialysis Centre at Al-Imamain Al-Kadhimain Teaching Hospital in Baghdad conducted a prospective cross-sectional study from November 1, 2023, to April 20, 2024.One hundred standard hemodialysis patients aged 18 years or older were recruited.Patients were classified based on anemia severity (Hb<8 g/dL versus Hb ≥8 g/dL) and PTH levels (<150 versus 150-600 pg/mL).ELISA quantified 25(OH)D, vitamin K, and intact PTH in the serum.Statistical techniques were employed for correlation and comparative analyses.Patients with severe anemia exhibited markedly reduced mean 25(OH)D levels (p=0.02).The levels of PTH and vitamin K were comparable throughout the anaemic groups (p=0.11
Source: ACTA Pharmaceutica Sciencia
Institutions: Baghdad Medical City, Nahrain University
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7130438809