Design, Synthesis, Characterization and Antibacterial potency evaluation of Novel 4-(1,3,4-oxadiazol-2-yl) phenol derivatives
Year: 2026
Type: article
Abstract: A series of novel sulfonate derivatives of 4-(1,3,4- oxadiazol-2-yl)phenol was synthesized. The reaction involves treatment of 4-(1,3,4-oxadiazol-2-yl)phenol with different sulfonyl chloride analogues 6a-f. The structure of the synthesized compounds is established based on FTIR, multi nuclear NMR (1H and 13C) spectral data and mass spectrometry. The synthesized compounds were subjected to pharmacological potency evaluation through in vitro antimicrobial activity with two different bacterial strains (Gram-ve bacteria E coli, Gram +ve bacteria S Aureus) at different concentrations ranging from 200μg/mL to 800μg/mL. Synthesized derivatives 6a, 6c, 6d and 6f were found to be active at higher to concentrations with ZOI range 11 to 17 in comparison to highly potent standard drug kanamycin.
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W7130516982