Evaluating the value of lactic dehydrogenase in anti-MDA5-positive Dermatomyositis associated with interstitial lung disease
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective This retrospective cohort study aimed to investigate the relationship between lactic dehydrogenase (LDH) and anti-melanoma differentiation-associated gene 5 antibodies-positive dermatomyositis (anti-MDA5-positive DM) associated with interstitial lung disease (ILD). Method A total of 168 anti-MDA5-positive DM patients with ILD underwent comprehensive evaluation, including LDH, anti-Ro-52 antibodies, serum ferritin determination, and lung high-resolution computed tomography (CT). Results The levels of LDH were significantly elevated in anti-MDA5-positive DM patients compared with the control group ( p < 0.01). Anti-Ro-52-positive patients exhibited significantly higher LDH levels than anti-Ro-52-negative patients ( p < 0.01). Patients with elevated serum ferritin exhibited markedly increased LDH levels compared with those with lower serum ferritin ( p < 0.01). After treatment, LDH levels significantly increased in patients with ILD deterioration ( p < 0.01), whereas LDH levels decreased in patients with ILD amelioration or stabilization ( p < 0.01). The LDH levels were significantly elevated in the death group compared to the survival group before treatment ( p = 0.02). Conclusion (1) The LDH levels were affected by anti-Ro-52 antibodies and serum ferritin. (2) The severity of ILD in anti-MDA5-positive DM patients was positively correlated with LDH, suggesting that LDH might serve as an effective assessment indicator to evaluate the changes in ILD in these patients. (3) Elevated LDH levels were a crucial indicator of poor prognosis in anti-MDA5-positive DM patients, warranting close attention from rheumatologists.
Source: Frontiers in Medicine
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7130656276