Year: 2026
Type: article
Study design: Observational Study
Abstract: Brain metastases represent the most frequent intracranial complication of bronchopulmonary cancers. We retrospectively analyzed 120 patients with lung cancer–related brain metastases treated at the Pierre and Marie Curie Center, Algiers, between 2011 and 2023, to describe their clinical and therapeutic characteristics. The cohort included 100 men and 20 women, with a mean age of 62 years. Brain metastases were present at diagnosis in 78% of cases, detected during staging in 13%, and occurred metachronously in 9%, with a mean delay of 18 months. Most patients presented with solitary brain lesions (79%). Adenocarcinoma was the predominant histological subtype (64%), followed by squamous cell carcinoma (20%) and small-cell lung cancer (10%). Surgical resection and radiotherapy were performed in 17% and 40% of patients, respectively. Median overall survival was 12.75 months. Brain metastases remain a frequent and poor prognostic event in lung cancer, and management should be individualized according to disease burden, performance status, number of brain lesions, and tumor biology, ideally within a multidisciplinary framework.
Institution: University of Blida
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7135389605