Additional file 11: of Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response
Year: 2016
Type: article
Abstract: Somatic hypermutation rates in selected IGHV segments according to clinical and immune status. SHM rates are shown according to clinical status (A, C, and E) and according to immune status (B, D, and F) measured as the proportion of mutations along the VH region [pM-VH (%)]. (A) SHM rates of IGHV1-2 regarding clinical status and (B) immune status. (C) SHM rates of IGHV1-18 regarding clinical status and (D) immune status. (E) SHM rates of IGHV1-69 regarding clinical status and (F) immune status. (DWS− A, green; DWS− Pc, dark green; DWS+ A, blue; DWS+ Pc, dark blue; primary infection acute, orange; primary infection Pc, brown; secondary infection acute, light purple; secondary infection Pc, dark purple) (Kruskal–Wallis test, Dunn’s correction for multiple testing, **p < 0.01, ***p < 0.001). (PDF 886 kb)
Source: Figshare
Authors: Godoy-Lozano, Elizabeth, Téllez-Sosa, Juan, Sánchez-González, Gilberto, Sámano-Sánchez, Hugo, Aguilar-Salgado, Andrés, Salinas-Rodríguez, Aarón, Cortina-Ceballos, Bernardo, Vivanco-Cid, Héctor, Hernández-Flores, Karina, Pfaff, Jennifer, Kahle, Kristen, Doranz, Benjamin, Gómez-Barreto, Rosa, Valdovinos-Torres, Humberto, López-Martínez, Irma, Rodriguez, Mario, Martínez-Barnetche, Jesús
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7137264992