Work

Critical Re-Examination of the Synthesis of Adamantyl Hydroperoxide

Year: 2026

Type: article

Abstract: This study investigates the synthesis of 1-hydroperoxyadamantane, addressing discrepancies in the prior literature. Our results demonstrate that previous authors were unable to obtain the claimed compound under the conditions they described. We confirmed that 1-hydroperoxyadamantane can be synthesized in good yields via the reaction of 1,3-dehydroadamantane with concentrated hydrogen peroxide in DCM. Structure of 1-hydroperoxyadamantane was confirmed by SC XRD analysis. These findings clarify the conditions necessary for successful synthesis of this compound and highlight the importance of comprehensive analytical verification. This study also provides a very detailed, repeatedly verified method for synthesizing 1,3-dehydroadamantane and a description of the necessary laboratory equipment.

Source: Molecules

DOI: 10.3390/molecules31071073

Authors: Ilya Nazarov, Daria Zapravdina, Anna Maximova, Ilya A. Yakushev, Victor Chapurkin, Vladimir Burmistrov

Institutions: Volgograd State Technical University, Russian Academy of Sciences, NS Kurnakova Institute of General and Inorganic Chemistry

Language: English

Topic: Chemical Synthesis and Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funders: MIREA - Russian Technological University, Ministry of Science and Higher Education of the Russian Federation