Lipid-based Nanocarriers for Oral Delivery of Poorly Water-soluble Drugs: a Comprehensive Review on Self-nanoemulsifying Drug Delivery Systems (snedds)
Year: 2026
Type: article
Abstract: Oral drug delivery is predominantly limited by the low aqueous solubility that leads to low dissolution rate and hence poor bioavailability. Lipid-based nanocarriers provide a logical answer to this challenges as they enhance solubilization, prevent drug degradation and escalate intestinal absorption. The classification, mechanisms, formulation techniques, and advantages and limitations of the major lipid-based systems (i.e., SLNs, NLCs, liposomes, niosomes SEDDSs and SNEDDS) are presented in this study. Especially self-nanoemulsifying systems are focussed because of its success in poorly water-soluble drugs. Comparative aspects of vesicular and non-vesicular systems are also highlighted. Solid SNEDDS and lipid-polymer hybrid nanocarriers are examples of future developments that have the potential to improve stability and performance. In general, lipid-based nanocarriers show promise as a means of improving oral bioavailability.
Institution: Uttarakhand Technical University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7149966919