Work

Total Synthesis of Isoriccardin C and Isoriccardin D Based on a Hydroxyl-Directed Palladium-Catalyzed Intramolecular C–H Alkenylation

Year: 2026

Type: article

Abstract: -alkenylation that forges the 18-membered macrocyclic core. This streamlined route enables the total synthesis with minimal reliance on protecting groups, and its modular nature offers a versatile platform for the construction of structural analogues.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6c00911

Authors: Pablo Losada, José Luis Mascareñas, Moisés Gulías

Institutions: Universidade de Santiago de Compostela, Centro Singular de Investigación en Química Biológica y Materiales Moleculares

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Xunta de Galicia, Instituto de Salud Carlos III, European Regional Development Fund, Agencia Estatal de Investigación